Seizures and Epilepsy in Autism Spectrum Disorder

Child Adolesc Psychiatr Clin N Am. 2020 Jul;29(3):483-500. doi: 10.1016/j.chc.2020.02.002. Epub 2020 Apr 3.


Epilepsy and autism frequently co-occur. Epilepsy confers an increased risk of autism and autism confers an increased risk of epilepsy. Specific epilepsy syndromes, intellectual disability, and female gender present a particular risk of autism in individuals with epilepsy. Epilepsy and autism are likely to share common etiologies, which predispose individuals to either or both conditions. Genetic factors, metabolic disorders, mitochondrial disorders, and immune dysfunction all can be implicated.

Keywords: Autism; Epilepsy; Epileptic encephalopathy; Genetics; Intellectual disability; Regression; Seizures.

Publication types

  • Review

MeSH terms

  • Autism Spectrum Disorder / epidemiology*
  • Autism Spectrum Disorder / genetics*
  • Autism Spectrum Disorder / physiopathology
  • Epilepsy / epidemiology*
  • Epilepsy / genetics*
  • Epilepsy / physiopathology
  • Humans
  • Intellectual Disability
  • Risk Factors
  • Seizures*