A Conceptual Discussion About the Basic Reproduction Number of Severe Acute Respiratory Syndrome Coronavirus 2 in Healthcare Settings

Laura Temime; Marie-Paule Gustin; Audrey Duval; Niccolò Buetti; Pascal Crépey; Didier Guillemot; Rodolphe Thiébaut; Philippe Vanhems; Jean-Ralph Zahar; David R M Smith; Lulla Opatowski

doi:10.1093/cid/ciaa682

A Conceptual Discussion About the Basic Reproduction Number of Severe Acute Respiratory Syndrome Coronavirus 2 in Healthcare Settings

Clin Infect Dis. 2021 Jan 23;72(1):141-143. doi: 10.1093/cid/ciaa682.

Authors

Laura Temime^{1

2}, Marie-Paule Gustin^{3

4}, Audrey Duval^{5

6}, Niccolò Buetti⁷, Pascal Crépey⁵, Didier Guillemot^{5

6

8}, Rodolphe Thiébaut^{9

10

11}, Philippe Vanhems^{4

12

13}, Jean-Ralph Zahar^{14

15}, David R M Smith^{1

5

6}, Lulla Opatowski^{5

6}

Affiliations

¹ MESuRS laboratory, Conservatoire national des arts et métiers, Paris, France.
² PACRI Unit, Institut Pasteur, Conservatoire national des arts et métiers, Paris, France.
³ Institute of Pharmaceutic and Biological Sciences, University Claude Bernard Lyon 1, Villeurbanne, France.
⁴ Emerging Pathogens Laboratory-Fondation Mérieux, International Center for Infectiology Research (CIRI), Inserm U1111, CNRS UMR5308, ENS de Lyon, Lyon, France.
⁵ Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, CESP, Anti-infective evasion and pharmacoepidemiology team, Montigny-Le-Bretonneux, France.
⁶ Institut Pasteur, Epidemiology and Modelling of Antibiotic Evasion unit, Paris, France.
⁷ UPRES-EA 7449 REPERES "Recherche en Pharmaco-Epidémiologie et Recours aux Soins" - EHESP - Université de Rennes, Rennes, France.
⁸ AP-HP Paris Saclay, Public Health, Medical Information, Clinical research, Le Kremlin-Bicêtre, France.
⁹ INSERM U1219 Bordeaux Population Health, Université de Bordeaux, Bordeaux, France.
¹⁰ INRIA SISTM team, Talence, France.
¹¹ Vaccine Research Institute, Créteil, France.
¹² Service d'Hygiène, Epidémiologie et Prévention, Hospices Civils de Lyon, F-69437, Lyon, France.
¹³ Inserm, F CRIN, Réseau Innovative Clinical Research in Vaccinology (I-REIVAC), Paris, France.
¹⁴ IAME, UMR1137, Inserm, Univ. Paris 13, Sorbonne Paris Cité, Paris, France.
¹⁵ Service de Microbiologie Clinique et Unité de Contrôle et de Prévention du Risque Infectieux, Groupe Hospitalier Paris Seine Saint-Denis, AP-HP, Bobigny, France.

Abstract

To date, no specific estimate of R0 for SARS-CoV-2 is available for healthcare settings. Using interindividual contact data, we highlight that R0 estimates from the community cannot translate directly to healthcare settings, with pre-pandemic R0 values ranging 1.3-7.7 in 3 illustrative healthcare institutions. This has implications for nosocomial COVID-19 control.

Keywords: COVID-19; basic reproduction number; hospital; modeling; transmission.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Basic Reproduction Number
COVID-19*
Delivery of Health Care
Humans
Pandemics
SARS-CoV-2*