Association Between Seroclearance of Hepatitis B Surface Antigen and Long-term Clinical Outcomes of Patients With Chronic HBV Infection: Systematic Review and Meta-analysis

Clin Gastroenterol Hepatol. 2020 May 27;S1542-3565(20)30748-5. doi: 10.1016/j.cgh.2020.05.041. Online ahead of print.


Background & aims: Seroclearance of hepatitis B surface antigen (HBsAg) is the desired endpoint of treatment for chronic hepatitis B virus (HBV) infection, according to guidelines. We performed a systematic review and meta-analysis to evaluate the strength of association between HBsAg seroclearance and long-term clinical outcomes.

Methods: We performed a systematic review of the PubMed, EMBASE, and Cochrane Library databases for articles that assessed HBsAg status and reported the incidence of hepatocellular carcinoma (HCC), liver decompensation, liver transplantation, and/or all-cause mortality during follow up. We performed a meta-analysis of rate ratios (RR) using a random effects model independently for each endpoint and for a composite endpoint.

Results: We analyzed data from 28 studies, comprising a total of 188,316 patients with chronic HBV infection (treated and untreated), and 1,486,081 person-years (P-Y) of follow up; 26 reported data on HCC, 7 on liver decompensation, and 13 on liver transplantation and/or death. The composite event rates were 0.19/1000 P-Y for the HBsAg seroclearance group and 2.45/1000 P-Y for the HBsAg-persistent group. Pooled RRs for the HBsAg seroclearance group were 0.28 for liver decompensation for liver decompensation (95% CI, 0.13-0.59; P=.001), 0.30 for HCC (95% CI, 0.20-0.44; P<.001), 0.22 for liver transplantation and/or death (95% CI, 0.13-0.39; P<.001), and 0.31 for the composite endpoint (95% CI, 0.23-0.43; 95% CI, .023-0.43; P<.001). No differences in RR estimates were observed among subgroups of different study or patient characteristics.

Conclusions: In a systematic review and meta-analysis, we found seroclearance of HBsAg to be significantly associated with improved patient outcomes. The results are consistent among different types of studies, in all patient subpopulations examined, and support the use of HBsAg seroclearance as a primary endpoint of trials of patients with chronic HBV infection.

Keywords: HBsAg; long-term outcomes; primary endpoint; viral hepatitis.