COVID-19: Transmission, prevention, and potential therapeutic opportunities

Clin Chim Acta. 2020 Sep;508:254-266. doi: 10.1016/j.cca.2020.05.044. Epub 2020 May 29.

Abstract

The novel coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global challenge. Despite intense research efforts worldwide, an effective vaccine and viable treatment options have eluded investigators. Therefore, infection prevention, early viral detection and identification of successful treatment protocols provide the best approach in controlling disease spread. In this review, current therapeutic options, preventive methods and transmission routes of COVID-19 are discussed.

Keywords: COVID-19; Prevention; SARS-CoV-2; Transmission; Treatment.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Antiviral Agents / therapeutic use
  • Betacoronavirus / drug effects*
  • Betacoronavirus / pathogenicity
  • COVID-19 / epidemiology*
  • COVID-19 / prevention & control
  • COVID-19 / therapy*
  • COVID-19 / transmission
  • COVID-19 Vaccines
  • Clinical Trials as Topic
  • Coronavirus Infections / epidemiology*
  • Coronavirus Infections / prevention & control
  • Coronavirus Infections / therapy*
  • Coronavirus Infections / transmission
  • Drug Repositioning
  • Humans
  • Immunization, Passive / methods
  • Immunologic Factors / therapeutic use
  • Molecular Targeted Therapy / methods
  • Pandemics* / prevention & control
  • Personal Protective Equipment
  • Physical Distancing
  • Pneumonia, Viral / epidemiology*
  • Pneumonia, Viral / prevention & control
  • Pneumonia, Viral / therapy*
  • Pneumonia, Viral / transmission
  • SARS-CoV-2
  • Viral Vaccines / biosynthesis

Substances

  • Adrenal Cortex Hormones
  • Antiviral Agents
  • COVID-19 Vaccines
  • Immunologic Factors
  • Viral Vaccines

Supplementary concepts

  • COVID-19 serotherapy