History of the Network Approach in Epilepsy Surgery

Ricardo Amorim-Leite; Madison Remick; William Welch; Taylor J Abel

doi:10.1016/j.nec.2020.03.011

History of the Network Approach in Epilepsy Surgery

Neurosurg Clin N Am. 2020 Jul;31(3):301-308. doi: 10.1016/j.nec.2020.03.011.

Authors

Ricardo Amorim-Leite¹, Madison Remick², William Welch³, Taylor J Abel⁴

Affiliations

¹ Department of Neurology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.
² Department of Neurological Surgery, University of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.
³ Division of Pediatric Neurology, Department of Pediatrics, University of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.
⁴ Department of Neurological Surgery, University of Pittsburgh, UPMC Children's Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA. Electronic address: abeltj@upmc.edu.

PMID: 32475480
DOI: 10.1016/j.nec.2020.03.011

Abstract

We provide a history and overview of the network approach to epilepsy surgery. Models of the epileptogenic zone (EZ) have evolved considerably over the years with more recent models accounting for the connectivity and network properties of epileptic foci. Next, we describe several examples of network phenotypes of focal epilepsy and how these have the potential to influence surgical decision-making and patient outcome. Future research will provide new insight into how network models of the EZ can determine optimal surgical interventions that improve seizure outcomes and optimize cognitive outcomes.

Keywords: Electrophysiology; Epileptogenic network; Frontal lobe; Stereoelectroencephalography; Temporal lobe.

Publication types

Historical Article
Review

MeSH terms

Animals
Brain / surgery*
Epilepsy / surgery*
History, 20th Century
History, 21st Century
Humans
Models, Neurological
Neural Pathways / surgery
Neurosurgical Procedures / history*
Neurosurgical Procedures / methods*
Seizures / surgery*