Epileptogenicity Mapping: A Quantitative Approach to Identify the Seizure Onset

Neurosurg Clin N Am. 2020 Jul;31(3):449-457. doi: 10.1016/j.nec.2020.03.006. Epub 2020 Apr 25.


During the presurgical evaluation of patients with focal refractory epilepsies, the spatial mapping of the seizure onset zone (SOZ) and seizure propagation networks critically depends on the use of different features extracted from the intracranial electroencephalogram (IEEG). The identification of the SOZ is usually based on visual inspection by highly qualified neurophysiologists. However, quantitative IEEG analyses have recently been developed by exploiting signal and image characteristics in order to improve and expedite the SOZ detection. Here, the authors briefly review some of the latest methods proposed by different research groups and then present the recent implementation in Brainstorm software.

Keywords: Computerized analysis; Epileptogenicity mapping; Intracranial electroencephalography; Seizure onset zone.

Publication types

  • Review

MeSH terms

  • Brain / physiopathology
  • Brain / surgery
  • Epilepsy / diagnosis*
  • Epilepsy / physiopathology
  • Epilepsy / surgery*
  • Humans
  • Neural Pathways / physiopathology
  • Neural Pathways / surgery
  • Neurosurgical Procedures / methods*
  • Preoperative Care / methods
  • Seizures / diagnosis*
  • Seizures / physiopathology
  • Seizures / surgery*
  • Signal Processing, Computer-Assisted
  • Software
  • Surgery, Computer-Assisted / methods*