Lung Manifestations of IgG4-related Disease. A multifaceted disorder. Presentation of two cases and short review of the literature

Sara Ramponi; Letizia Gnetti; Maurizio Marvisi; Giuseppina Bertorelli; Alfredo Chetta

doi:10.36141/svdld.v35i1.6161

Lung Manifestations of IgG4-related Disease. A multifaceted disorder. Presentation of two cases and short review of the literature

Sarcoidosis Vasc Diffuse Lung Dis. 2018;35(1):74-80. doi: 10.36141/svdld.v35i1.6161. Epub 2018 Apr 28.

Authors

Sara Ramponi^{1

2}, Letizia Gnetti³, Maurizio Marvisi¹, Giuseppina Bertorelli², Alfredo Chetta²

Affiliations

¹ Dept. of Internal Medicine, Istituto Figlie di San Camillo, Cremona.
² Pathology Unit, University Hospital of Parma, Parma, Italy.
³ Respiratory Unit, Dept. of Medicine and Surgery, University Hospital of Parma.

Abstract

Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a recently described systemic inflammatory disease associated with elevated circulating levels of IgG4. IgG4-RD may affect one or more organs and lesions can present synchronously or metachronously in different organs. Pulmonary involvement of IgG4-related disease includes airway, lung parenchyma, pleura and mediastinum. In this article, we report two cases of IgG4-RD to show the multifaceted manifestations of this disease in the lungs. (Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 74-80).

Keywords: IgG4 related disease; lung; pleura.