Abstract
We recently published a report validating point-of-care rapid diagnostic tests (RDT) for the diagnosis of Hepatitis B virus (HBV) infection in serum. In the current report, we validated a whole-blood RDT for HBsAg in the form of a test-strip. The test was validated in 55 HBV positive individuals across all genotypes other than F, and in 20 HBV negative individuals in the Netherlands. The RDT showed 100% sensitivity and specificity. The low cost and use in whole blood allows this RDT to be useful in resource-limited locations, further validation in such settings will be of importance.
Copyright: © 2020 The Author(s).
Publication types
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Letter
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Validation Study
MeSH terms
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Adolescent
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Adult
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Antiviral Agents / therapeutic use
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Child
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Child, Preschool
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DNA, Viral / blood
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Female
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Hepatitis B Surface Antigens / blood*
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Hepatitis B e Antigens / blood
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Hepatitis B, Chronic / blood
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Hepatitis B, Chronic / diagnosis*
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Hepatitis B, Chronic / drug therapy
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Humans
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Male
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Middle Aged
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Reagent Kits, Diagnostic
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Reproducibility of Results
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Sensitivity and Specificity
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Viral Load
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Young Adult
Substances
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Antiviral Agents
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DNA, Viral
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Hepatitis B Surface Antigens
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Hepatitis B e Antigens
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Reagent Kits, Diagnostic