Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Aug;44(8):e13272.
doi: 10.1111/jfbc.13272. Epub 2020 Jun 1.

Hypolipidemic and antioxidant activities of Trichosanthes kirilowii maxim seed oil and flavonoids in mice fed with a high-fat diet

Zongkun Hou  1 , Liancai Zhu  1 , Run Meng  1 , Bochu Wang  1
Affiliations

Hypolipidemic and antioxidant activities of Trichosanthes kirilowii maxim seed oil and flavonoids in mice fed with a high-fat diet

Zongkun Hou et al. J Food Biochem. 2020 Aug.

Abstract

Trichosanlhes kirilowii Maxim seed oil (TSO) is rich in conjugated linolenic acids, and the flavonoids (FLA) combined with n-3 fatty acids can effectively change the plasma antioxidant capacity. Hyperlipidemia and oxidative stress are one of the most important risk factors for cardiovascular disease. This study aims to evaluate the effect of the TSO, FLA, and TSO combined with FLA (TSOFLA) intake on hyperlipemia mice. TSO and TSOFLA administration resulted in a significant decline in serum levels of total cholesterol, triglycerides, and low density lipoprotein-cholesterol. TSOFLA improved the hepatic and serum antioxidant status as assessed by superoxide dismutase, glutathione peroxidase activities, and reduced the levels of lipid peroxidation. Hematoxylin-eosin staining of liver and aorta tissue has shown a marked reduction of the hyperlipidemia-induced lesions by gavage TSOFLA. Compared with TSO and FLA, TSOFLA has more significant hypolipidemic and antioxidant activities, which effects may be correlated to the synergy between TSO and FLA. PRACTICAL APPLICATIONS: Dyslipidemia is a common metabolic disorder, which is characterized by triglyceride levels increased, total cholesterol, and low-density lipoprotein cholesterol. Lipid-lowering treatment can reduce the expansion of coronary atherosclerosis, and particular the dietary lipids have important roles in controlling the concentrations of these risk factors. This is the first study evaluating the hypolipidemic and antioxidant activities effects of Trichosanlhes kirilowii Maxim seed oil (TSO), flavonoids (FLA), and TSO combined with FLA (TSOFLA) intake on hyperlipemia mice caused by a high-fat diet. The pharmacological effects of dietary TSOFLA are correlated to its high content of unsaturated fatty acids and flavonoids. This information can be of interest to the development of food supplements in the field of diseases associated with high-fat intakes such as cardiovascular diseases and adiposis.

Keywords: Trichosanthes kirilowii maxim seed oil; antioxidant activity; flavonoids; high-fat diet; hypolipidemic.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

REFERENCES

    1. Albers, J. J., Slee, A., Fleg, J. L., O'Brien, K. D., & Marcovina, S. M. (2016). Relationship of baseline HDL subclasses, small dense LDL and LDL triglyceride to cardiovascular events in the AIM-HIGH clinical trial. Atherosclerosis, 251, 454-459. https://doi.org/10.1016/j.atherosclerosis.2016.06.019
    1. Arao, K., Wang, Y. M., Inoue, N., Hirata, J., Cha, J. Y., Nagao, K., & Yanagita, T. (2004). Dietary effect of pomegranate seed oil rich in 9cis, 11trans, 13cis conjugated linolenic acid on lipid metabolism in obese, hyperlipidemic OLEFLA rats. Lipids in Health and Disease, 3(1), 24. https://doi.org/10.1186/1476-511X-3-24
    1. Babitha, M. P., Bhat, S. G., Prakash, H. S., & Shetty, H. S. (2002). Differential induction of superoxide dismutase in downy mildew-resistant and -susceptible genotypes of pearl millet. Plant Pathology, 51(4), 480-486. https://doi.org/10.1046/j.1365-3059.2002.00733.x
    1. Binkoski, A. E., Kris-Etherton, P. M., Wilson, T. A., Mountain, M. L., & Nicolosi, R. J. (2005). Balance of unsaturated fatty acids is important to a cholesterol-lowering diet: Comparison of mid-oleic sunflower oil and olive oil on cardiovascular disease risk factors. Journal of the American Dietetic Association, 105(7), 1080-1086. https://doi.org/10.1016/j.jada.2005.04.009
    1. Bolt, H. M., & Stewart, J. D. (2012). Antioxidant activity of food constituents: Relevance for the risk of chronic human diseases. Archives of Toxicology, 86(3), 343-344. https://doi.org/10.1007/s00204-012-0812-8

Publication types

LinkOut - more resources