The papers in this special issue were mainly derived from sessions at the International Botanical Congress in July 2011 in Melbourne, and at the ComBio meeting in Cairns, September 2011. They make contributions towards one of the most burning issues we face today: increasing sustainable crop production to provide sufficient high quality food to feed an ever increasing global human population, all in the face of climate change. Plant and crop science will have a major part in ensuring that agricultural production can meet these multiple demands. Contributions in this volume go beyond raising issues and highlighting potential effects of climate change factors, but also point out ways to better adapt to the inevitable.