The neurological manifestations of COVID-19: a review article

Neurol Sci. 2020 Jul;41(7):1667-1671. doi: 10.1007/s10072-020-04486-3. Epub 2020 Jun 1.


Results: Various neurological manifestations have been reported in the literature associated with COVID-19, which in the current study are classified into Central Nervous System (CNS) related manifestations including headache, dizziness, impaired consciousness, acute cerebrovascular disease, epilepsy, and Peripheral Nervous System (PNS) related manifestations such as hyposmia/anosmia, hypogeusia/ageusia, muscle pain, and Guillain-Barre syndrome.

Conclusion: During the current context of COVID-19 pandemic, physicians should be aware of wide spectrum of neurological COVID-19 sign and symptoms for early diagnosis and isolation of patients. In this regard, COVID-19 has been associated with many neurological manifestations such as confusion, anosmia, and ageusia. Also, various evidences support the possible CNS roles in the COVID-19 pathophysiology. In this regard, further investigation of CNS involvement of SARS-COV-2 is suggested.

Keywords: COVID-19; Coronaviruses; Neurological symptoms; SARS-COV-2.

Publication types

  • Review

MeSH terms

  • Betacoronavirus*
  • COVID-19
  • Cerebrovascular Disorders / physiopathology
  • Cerebrovascular Disorders / virology
  • Coronavirus Infections / complications
  • Coronavirus Infections / pathology*
  • Coronavirus Infections / virology*
  • Headache / complications
  • Headache / virology
  • Humans
  • Nervous System Diseases / epidemiology
  • Nervous System Diseases / virology*
  • Pandemics
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / pathology*
  • Pneumonia, Viral / virology*
  • SARS-CoV-2