Neuroprotective and Antioxidant Activity of Arachidonoyl Choline, Its Bis-Quaternized Analogues and Other Acylcholines

Dokl Biochem Biophys. 2020 Mar;491(1):93-97. doi: 10.1134/S1607672920020027. Epub 2020 Jun 1.

Abstract

The antioxidant activity and protective effect in the toxicity model of H2O2 were studied for arachidonic (AA-CHOL), docosahexaenoic (DHA-CHOL), linoleic (Ln-CHOL), and oleic (Ol-CHOL) fatty acids, as well as arachidonoyl dicholine (AA-diCHOL) and O-arachidonoyl bistetramethylaminoisopropanol (ABTAP). AA-CHOL, DHA-CHOL and Ln-CHOL provided a 20% increase in cell survival. AA-CHOL, AA-diCHOL, Ol-CHOL, and ABTAP had a radical-scavenging effect in the ABTS test, approximately equal to the activity of a standard radical scavenger Trolox.

Keywords: acylcholines; antioxidant activity; bisquaternized acylcholines; neuroprotection.

MeSH terms

  • 2-Propanol / chemistry
  • Antioxidants / chemistry*
  • Arachidonic Acid / chemistry
  • Arachidonic Acids / chemistry*
  • Cell Line, Tumor
  • Choline / chemistry*
  • Chromans / chemistry
  • Docosahexaenoic Acids / chemistry
  • Drug Screening Assays, Antitumor
  • Fatty Acids
  • Free Radicals / chemistry
  • Humans
  • Hydrogen Peroxide / chemistry
  • Linoleic Acid / chemistry
  • Oleic Acid / chemistry

Substances

  • Antioxidants
  • Arachidonic Acids
  • Chromans
  • Fatty Acids
  • Free Radicals
  • arachidonoylcholine
  • Docosahexaenoic Acids
  • Arachidonic Acid
  • Oleic Acid
  • Linoleic Acid
  • Hydrogen Peroxide
  • Choline
  • 2-Propanol
  • 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid