Repurposing developmental mechanisms in the adult nervous system

Curr Opin Genet Dev. 2020 Dec;65:14-21. doi: 10.1016/j.gde.2020.04.006. Epub 2020 May 30.


Molecules and cellular processes important for nervous system development can be repurposed in adulthood for the regulation of adult neurogenesis, synaptic plasticity, and neural regeneration following injury or degeneration. Efforts to recapitulate neural development in order to ameliorate injury or disease are promising, but these often fall short of functional restoration due in part to our incomplete understanding of how these damaged circuits initially developed. Despite these limitations, such strategies provide hope that harnessing developmental mechanisms can restore nervous system functions following damage or disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adult
  • Humans
  • Nerve Regeneration*
  • Neural Pathways / physiology*
  • Neurogenesis*
  • Neuronal Plasticity*