Systems biology of host-Candida interactions: understanding how we shape each other

Curr Opin Microbiol. 2020 Dec:58:1-7. doi: 10.1016/j.mib.2020.04.001. Epub 2020 May 30.

Abstract

Candida albicans is both a member of the human mucosal microbiota and a common agent of invasive fungal disease. Systems biology approaches allow for analysis of the interactions between this fungus and its mammalian host. Framing these studies by considering how C. albicans and its host construct the niche the other occupies provides insight into how these interactions shape the ecosystems, behavior, and evolution of each organism. Here, we discuss recent work on multiscale systems biology approaches for examining C. albicans in relation to the host ecosystem to identify the emergent properties of the interactions and new variables that can be targeted for development of therapeutic strategies.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Candida albicans / genetics
  • Candida albicans / physiology*
  • Candidiasis / microbiology*
  • Host-Pathogen Interactions
  • Humans
  • Systems Biology / methods*
  • Systems Biology / trends