Ultra-widefield fundus fluorescein angiography findings in patients with ankylosing spondylitis experiencing uveitis

Int Ophthalmol. 2020 Oct;40(10):2627-2634. doi: 10.1007/s10792-020-01443-z. Epub 2020 Jun 2.

Abstract

Aim: To evaluate ultra-widefield fundus fluorescein angiography (FFA) findings in cases of ankylosing spondylitis (AS)-associated uveitis.

Materials and methods: Forty-five eyes of 23 AS patients followed up with a diagnosis of uveitis were included.

Results: Sixteen (69.6%) men and seven (30.4%) women with a mean age of 46.26 ± 10.87 years were included in the study. Retinal vascular leakage was observed in 19 (42.2%) eyes at FFA, diffuse in six (13.3%) and peripheral in 13 (28.9%) eyes. Active anterior uveitis attack was present in seven (36.8%) eyes with vascular leakage at FFA, while no active uveitis findings were present in 12 (63.15%) eyes. No statistical relation was determined between peripheral and diffuse leakage and active uveitis (p = 0.195). No significant association was also determined between both diffuse and peripheral leakage and visual acuity (p = 0.066).

Conclusion: We observed widespread retinal vascular leakage at UWF angiography in AS patients (in eyes undergoing active uveitis attacks and inactive eyes).

Keywords: Acute anterior uveitis; Ankylosing spondylitis; Fluorescein angiography; Inflammation.

MeSH terms

  • Adult
  • Female
  • Fluorescein Angiography
  • Fundus Oculi
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Spondylitis, Ankylosing* / complications
  • Spondylitis, Ankylosing* / diagnosis
  • Uveitis* / diagnosis
  • Uveitis, Anterior* / diagnosis
  • Visual Acuity