Management of Chronic Bacterial Prostatitis

Curr Urol Rep. 2020 Jun 3;21(7):29. doi: 10.1007/s11934-020-00978-z.


Purpose of review: We conducted a review of the literature describing the most up-to-date diagnosis and treatment options of chronic bacterial prostatitis.

Recent findings: Recurrence after oral antimicrobial therapy is common, due in part to the rising rates of antimicrobial resistance and inability to completely clear the offending bacteria from the prostate following prostatitis. Recent literature has described various treatment options for chronic bacterial prostatitis refractory to conventional antimicrobial agents, including the use of alternative agents such as fosfomycin, direct antimicrobial injections into the prostate, surgical removal of infected prostatic tissue, chronic oral antibiotic suppression, and an emerging novel therapy utilizing bacteriophages to target antibiotic resistant bacteria. Management of chronic bacterial prostatitis, especially recurrence after oral antimicrobial treatment, remains challenging. This review highlights an urgent need for further evidence assessing the efficacy and safety of treatment modalities for chronic bacterial prostatitis refractory to conventional oral antimicrobials.

Keywords: Antibiotics; Antimicrobial resistance; Chronic bacterial prostatitis; Phage therapy; Recurrence; Surgery.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Infections / complications
  • Bacterial Infections / diagnosis
  • Bacterial Infections / therapy*
  • Bacteriophages
  • Chronic Disease
  • Drug Resistance, Bacterial
  • Humans
  • Male
  • Prostatectomy
  • Prostatitis / diagnosis
  • Prostatitis / microbiology
  • Prostatitis / therapy*
  • Recurrence


  • Anti-Bacterial Agents