Mesenchymal Stem Cells for Coronavirus (COVID-19)-Induced Pneumonia: Revisiting the Paracrine Hypothesis with New Hopes?

Selçuk Öztürk; Ayşe Eser Elçin; Yaşar Murat Elçin

doi:10.14336/AD.2020.0403

Mesenchymal Stem Cells for Coronavirus (COVID-19)-Induced Pneumonia: Revisiting the Paracrine Hypothesis with New Hopes?

Aging Dis. 2020 May 9;11(3):477-479. doi: 10.14336/AD.2020.0403. eCollection 2020 May.

Authors

Selçuk Öztürk¹, Ayşe Eser Elçin¹, Yaşar Murat Elçin¹

Affiliation

¹ Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Faculty of Science, Ankara University, Ankara, Turkey.

Abstract

Mesenchymal stem cells (MSCs) bear a promising potential for regenerative medicine therapies and they repair damaged tissue through secretion of immune modulatory and anti-inflammatory molecules acting in a paracrine fashion. Coronavirus disease 2019 (COVID-19) has spread all over the world with high morbidity and mortality rates and there is no specific treatment for this infection. A recent study published in the journal reports that MSC infusion is safe and effective in patients suffering from COVID-19 induced pneumonia. In the light of this study and previous reports, we make additional comments about possible therapeutic effects of MSCs in COVID-19 infection.

Keywords: COVID-19; cell transplantation; immunomodulation; mesenchymal stem cells; pneumonia.