Diagnostic approach in parenchymal lung diseases: transbronchial lung biopsy or cryobiopsy?

Turk J Med Sci. 2020 Oct 22;50(6):1535-1539. doi: 10.3906/sag-1910-47.


Background/aim: Diagnosis of interstitial lung diseases requires a multidisciplinary approach, and a gold standard for histological diagnosis is open lung biopsy. Transbronchial lung biopsy (TBLB) and in recent years an alternative method, cryobiopsy (TBLC), are used for the diagnosis of parenchymal lung lesions. The aim of this study is to compare the efficacy of concomitant conventional TBLB and TBLC.

Materials and methods: A total of 82 patients who underwent TBLC for diagnosis of diffuse parenchymal lung diseases at Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital between 2015 and 2018 were screened retrospectively and included in the study. Of the patients, 53.7% (n: 44) were male, and 46.4% (n:38) of them were female. The mean age was 58.37 (±9.33) years. First TBLB and then TBLC were performed to all patients in the same session and their diagnostic performances were compared.

Results: Although both procedures were done in the same session, 45 patients (54.9%) were diagnosed with TBLB and 75 patients (91.5%) were diagnosed with TBLC (P ˂ 0.001). Hemorrhage was observed in 39 patients (47.6%), but only one had a massive hemorrhage. Pneumothorax was observed in 6 patients (7.3%) and none of them required tube drainage.

Conclusion: Transbronchial lung cryobiopsy is a promising technique for the diagnosis of parenchymal lung diseases compared to transbronchial lung biopsy.

Keywords: parenchymal lung disease; transbronchial lung cryobiopsy; Transbronchial lung biopsy.

MeSH terms

  • Aged
  • Biopsy* / adverse effects
  • Biopsy* / methods
  • Biopsy* / statistics & numerical data
  • Female
  • Hemorrhage / epidemiology
  • Hemorrhage / etiology
  • Humans
  • Lung / pathology*
  • Lung / surgery
  • Lung Diseases, Interstitial* / diagnosis
  • Lung Diseases, Interstitial* / pathology
  • Lung Diseases, Interstitial* / surgery
  • Male
  • Middle Aged
  • Pneumothorax / epidemiology
  • Pneumothorax / etiology
  • Postoperative Complications / epidemiology
  • Retrospective Studies