Gut Microbial Metabolites and Blood Pressure Regulation: Focus on SCFAs and TMAO

Physiology (Bethesda). 2020 Jul 1;35(4):275-284. doi: 10.1152/physiol.00004.2020.


Shifts in the gut microbiome play a key role in blood pressure regulation, and changes in the production of gut microbial metabolites are likely to be a key mechanism. Known gut microbial metabolites include short-chain fatty acids, which can signal via G-protein-coupled receptors, and trimethylamine-N oxide. In this review, we provide an overview of gut microbial metabolites documented thus far to play a role in blood pressure regulation.

Keywords: G-protein-coupled receptors; blood pressure; gut microbial metabolite; hypertension.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Blood Pressure / physiology
  • Fatty Acids, Volatile / metabolism*
  • Gastrointestinal Microbiome
  • Humans
  • Hypertension / metabolism
  • Hypertension / microbiology*
  • Hypertension / physiopathology*
  • Methylamines / metabolism*


  • Fatty Acids, Volatile
  • Methylamines
  • trimethyloxamine