Pasteurella multocida is the most common cause of soft tissue infection in humans following bites or scratches from dogs and cats. Inoculation with P multocida typically results in soft tissue infection. However, respiratory and other serious invasive infections such as bacteremia, meningitis, and endocarditis may also occur, especially in the elderly, immunocompromised, and neonates. P multocida infections are almost universally penicillin-sensitive, making this the first-line treatment. In rare cases of penicillin resistance, cephalosporins (2nd and 3rd generation), fluoroquinolones, or tetracyclines can be used.
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