Of Mice and Men: NAD+ Boosting with Niacin Provides Hope for Mitochondrial Myopathy Patients

Abstract

In this issue of Cell Metabolism, Pirinen et al. (2020) show that disruption in NAD⁺ homeostasis is a key component of the pathogenesis of mitochondrial myopathy in humans that can be targeted by the administration of the NAD⁺ precursor niacin, identifying NAD⁺ boosting as a potential treatment for this devastating disease.