Break on Through: Golgi-Derived Vesicles Aid in Mitochondrial Fission

Cell Metab. 2020 Jun 2;31(6):1047-1049. doi: 10.1016/j.cmet.2020.05.010.


Mitochondrial fission is sustained through contact with several organelles, including the endoplasmic reticulum, lysosomes, and the actin cytoskeleton. Nagashima et al. (2020) now demonstrate that PI(4)P-containing Golgi-derived vesicles also modulate mitochondrial fission, driven by Arf1 and PI(4)KIIIβ activity, identifying a new organelle contact involved in maintaining mitochondrial homeostasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Endoplasmic Reticulum / metabolism
  • Golgi Apparatus* / metabolism
  • Lysosomes / metabolism
  • Mitochondria
  • Mitochondrial Dynamics*