Linking bodily, environmental and mental states in the self-A three-level model based on a meta-analysis

Neurosci Biobehav Rev. 2020 Aug;115:77-95. doi: 10.1016/j.neubiorev.2020.05.004. Epub 2020 May 31.

Abstract

Current researchers mostly agree that the self consists of both bodily and non-bodily environmental information. The neural mechanism underlying the integration of this information remains unclear. In this study, we propose a neural model subdividing self-processing into three intimately connected levels with different extension: Interoceptive-processing, Exteroceptive-processing and Mental-self-processing. We applied ALE meta-analyses on neuroimaging studies to analyze their neural patterns. Our results show common involvement of insula across all three levels including differentiation of self and familiarity. Common activities in Exteroceptive- and Mental-self-processing were found in the anteromedial prefrontal cortex (AMPFC) and the temporal parietal junction (TPJ), suggesting that the two regions likely serve basic functions in differentiation and integration of self-other information. Finally, Mental-self-processing involves extensive regions such as the cingulate cortex and medial prefrontal cortex, in addition to the insula, AMPFC and TPJ, which could specialize in adding self-relatedness to environment information. We conclude that there is a gradient organization in self-processing, through which body-environment information is integrated for the self via propagation from Interoceptive-processing to Mental-self-processing.

Keywords: AMPFC; Exteroception; Familiarity; Insula; Interoception; TPJ.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cerebral Cortex*
  • Heart Rate
  • Humans
  • Magnetic Resonance Imaging*