COVID-19 diagnostics in context

Ralph Weissleder; Hakho Lee; Jina Ko; Mikael J Pittet

doi:10.1126/scitranslmed.abc1931

COVID-19 diagnostics in context

Sci Transl Med. 2020 Jun 3;12(546):eabc1931. doi: 10.1126/scitranslmed.abc1931.

Authors

Ralph Weissleder^{1

2

3}, Hakho Lee⁴, Jina Ko⁴, Mikael J Pittet⁴

Affiliations

¹ Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA. ralph_weissleder@hms.harvard.edu.
² Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
³ Division of Interventional Radiology, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA.
⁴ Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA.

PMID: 32493791
DOI: 10.1126/scitranslmed.abc1931

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has highlighted the need for different types of diagnostics, comparative validation of new tests, faster approval by federal agencies, and rapid production of test kits to meet global demands. In this Perspective, we discuss the utility and challenges of current diagnostics for COVID-19.

Publication types

Comparative Study
Review

MeSH terms

Adaptive Immunity
Antigens, Viral / analysis
Betacoronavirus* / genetics
Betacoronavirus* / immunology
COVID-19
Clinical Laboratory Techniques / economics
Clinical Laboratory Techniques / methods
Coronavirus Infections / diagnosis*
Coronavirus Infections / epidemiology
Coronavirus Infections / immunology
Costs and Cost Analysis
Cross Reactions
Humans
Immunity, Innate
Pandemics
Pneumonia, Viral / diagnosis*
Pneumonia, Viral / epidemiology
Pneumonia, Viral / immunology
RNA, Viral / analysis
RNA, Viral / genetics
SARS-CoV-2
Serologic Tests / methods
Translational Research, Biomedical
United States / epidemiology
Viral Load / immunology

Substances

Antigens, Viral
RNA, Viral