Breast Pathology That Contributes to Dysfunction of Human Lactation: a Spotlight on Nipple Blebs

J Mammary Gland Biol Neoplasia. 2020 Jun;25(2):79-83. doi: 10.1007/s10911-020-09450-7. Epub 2020 Jun 3.


Nipple blebs are blister-like fibrinous lesions that form on the surface of the nipple during lactation, and can result in orifice obstruction and mastitis. They likely result from superficial extension of underlying ductal plugging, and can present concurrently with hyperlactation and mammary dysbiosis. Despite their prevalence, few formal reports on nipple blebs exist. In this perspective, we review the experience of a breastfeeding medicine practice that receives referrals for patients with nipple blebs, and provide preliminary insight into etiology, management, and outcomes of these lesions.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Blister / drug therapy*
  • Blister / epidemiology
  • Breast Feeding / adverse effects*
  • Female
  • Humans
  • Lactation Disorders / etiology
  • Lactation Disorders / prevention & control*
  • Nipples / abnormalities
  • Nipples / drug effects*


  • Anti-Bacterial Agents