Clinical Manifestations in Children with Staphylococcal Bacteremia Positive for Panton-Valentine Leucocidin: A Nationwide Survey in a Low Methicillin-Resistance Setting

Allan Bybeck Nielsen; Anders Rhod Larsen; Andreas Petersen; Henrik Carl Schønheyder; Henrik Westh; Thomas Benfield; Ulrikka Nygaard

doi:10.1097/INF.0000000000002722

Clinical Manifestations in Children with Staphylococcal Bacteremia Positive for Panton-Valentine Leucocidin: A Nationwide Survey in a Low Methicillin-Resistance Setting

Pediatr Infect Dis J. 2020 Sep;39(9):e274-e276. doi: 10.1097/INF.0000000000002722.

Authors

Allan Bybeck Nielsen¹, Anders Rhod Larsen², Andreas Petersen², Henrik Carl Schønheyder³, Henrik Westh⁴, Thomas Benfield⁵, Ulrikka Nygaard⁶

Affiliations

¹ From the Department of Pediatrics and Adolescent Medicine.
² Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.
³ Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark.
⁴ Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre, Denmark.
⁵ Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
⁶ Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Denmark.

PMID: 32496412
DOI: 10.1097/INF.0000000000002722

Abstract

A total of 714 pediatric cases of Staphylococcus aureus bacteremia were identified from 2008 to 2015 in Denmark; 98% were methicillin-susceptible S. aureus (MSSA). Fifteen isolates (2,1%) were Panton-Valentine leucocidin positive (0.17/100,000 children/year) and 87% MSSA. Eight cases (53%) were severe, including all pneumonia cases. Panton-Valentine leucocidin positive Staphylococcus aureus bacteremia is rare in our setting with high MSSA-prevalence. Half of the cases were uncomplicated.

MeSH terms

Adolescent
Anti-Bacterial Agents / therapeutic use
Bacteremia / drug therapy
Bacteremia / epidemiology*
Bacterial Toxins / blood*
Child
Denmark / epidemiology
Exotoxins / blood*
Humans
Infant
Infant, Newborn
Leukocidins / blood*
Methicillin-Resistant Staphylococcus aureus / drug effects
Microbial Sensitivity Tests
Prevalence
Staphylococcal Infections / blood*
Staphylococcal Infections / drug therapy
Staphylococcal Infections / epidemiology*
Staphylococcus aureus / drug effects
Staphylococcus aureus / pathogenicity*
Virulence Factors / blood*

Substances

Anti-Bacterial Agents
Bacterial Toxins
Exotoxins
Leukocidins
Panton-Valentine leukocidin
Virulence Factors