Breast Milk Modulates Transgenerational Immune Inheritance

Jakob Zimmermann; Andrew J Macpherson

doi:10.1016/j.cell.2020.05.030

Breast Milk Modulates Transgenerational Immune Inheritance

Cell. 2020 Jun 11;181(6):1202-1204. doi: 10.1016/j.cell.2020.05.030. Epub 2020 Jun 3.

Authors

Jakob Zimmermann¹, Andrew J Macpherson²

Affiliations

¹ Maurice Müller Laboratories (Department for BioMedical Research), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3008 Bern, Switzerland.
² Maurice Müller Laboratories (Department for BioMedical Research), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3008 Bern, Switzerland. Electronic address: andrew.macpherson@dbmr.unibe.ch.

PMID: 32497500
DOI: 10.1016/j.cell.2020.05.030

Abstract

ROR-γt⁺ regulatory T cells (Tregs) of the colon can prevent excessive inflammation but also delay pathogen clearance. How these cells are regulated has remained elusive. In this issue of Cell, Ramanan et al. find that the set-point for ROR-γt⁺ Tregs is non-genetically maternally inherited during a critical time window after birth through immunoglobulin A present in breast milk.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Female
Gastrointestinal Microbiome*
Humans
Milk, Human
Nuclear Receptor Subfamily 1, Group F, Member 3
T-Lymphocytes, Regulatory*
Th17 Cells

Substances

Nuclear Receptor Subfamily 1, Group F, Member 3