Non-invasive lobular neoplasia of the breast: Morphologic features, clinical presentation, and management dilemmas

Breast J. 2020 Jun;26(6):1148-1155. doi: 10.1111/tbj.13857. Epub 2020 Jun 4.


The designation of noninvasive lobular neoplasia applies to atypical epithelial proliferations composed of noncohesive cells secondary to loss or functional alteration of E-cadherin-mediated cell adhesion. The morphologic spectrum of noninvasive lobular neoplasia encompasses atypical lobular hyperplasia (ALH) and classic lobular carcinoma in situ (classic LCIS) and two LCIS variants, namely florid LCIS (F-LCIS) and pleomorphic LCIS (P-LCIS), as defined in the World Health Organization (WHO) Classification of Tumors of the Breast 5th ed. Herein, we review the morphologic, immunohistochemical, and molecular features of noninvasive lobular neoplasia, with special emphasis on F-LCIS and P-LCIS. We also review imaging features, management at core needle biopsy, upgrade rates at surgical excision, and clinical management dilemmas.

Keywords: atypical lobular hyperplasia (ALH); florid lobular carcinoma in situ (FLCIS); lobular carcinoma in situ (LCIS); pleomorphic lobular carcinoma in situ (PLCIS); upgrade.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Biopsy, Large-Core Needle
  • Breast / diagnostic imaging
  • Breast / pathology
  • Breast / surgery
  • Breast Carcinoma In Situ* / diagnostic imaging
  • Breast Carcinoma In Situ* / genetics
  • Breast Carcinoma In Situ* / surgery
  • Breast Neoplasms* / genetics
  • Breast Neoplasms* / pathology
  • Breast Neoplasms* / therapy
  • Carcinoma in Situ* / pathology
  • Carcinoma, Lobular* / diagnostic imaging
  • Carcinoma, Lobular* / genetics
  • Carcinoma, Lobular* / therapy
  • Female
  • Humans
  • Hyperplasia / pathology