Antidementia effects of Enterococcus faecalis 2001 are associated with enhancement of hippocampal neurogenesis via the ERK-CREB-BDNF pathway in olfactory bulbectomized mice

Physiol Behav. 2020 Sep 1:223:112997. doi: 10.1016/j.physbeh.2020.112997. Epub 2020 Jun 3.

Abstract

Our previous study showed that Enterococcus faecalis 2001 (EF-2001) suppresses colitis-induced depressive-like behavior through the enhancement of hippocampal neurogenesis in mice. In the present study, we investigated the effect of EF-2001 on the cognitive behavior of olfactory bulbectomized (OBX) mice and its molecular mechanisms. The OBX-induced cognitive dysfunction was significantly suppressed by EF-2001. Moreover, EF-2001 also recovered the reductions in p-ERK1/2, p-CREB, BDNF and DCX levels and in neurogenesis observed in the hippocampus of OBX mice. These results suggest that EF-2001-induced antidementia effects are associated with enhanced hippocampal neurogenesis through the ERK-CREB-BDNF pathway.

Keywords: Antidementia effect; Brain-derived neurotrophic factor; EF-2001; Hippocampus; Neurogenesis; Olfactory bulbectomy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain-Derived Neurotrophic Factor* / metabolism
  • Depression
  • Doublecortin Protein
  • Enterococcus faecalis* / metabolism
  • Hippocampus / metabolism
  • MAP Kinase Signaling System
  • Mice
  • Neurogenesis
  • Olfactory Bulb / metabolism
  • Olfactory Bulb / surgery

Substances

  • Brain-Derived Neurotrophic Factor
  • Dcx protein, mouse
  • Doublecortin Protein