Potential role of statins in COVID-19

Int J Infect Dis. 2020 Jul;96:615-617. doi: 10.1016/j.ijid.2020.05.115. Epub 2020 Jun 2.

Abstract

Patients with COVID-19 infection have an increased risk of cardiovascular complications and thrombotic events. Statins are known for their pleiotropic anti-inflammatory, antithrombotic and immunomodulatory effects. They may have a potential role as adjunctive therapy to mitigate endothelial dysfunction and dysregulated inflammation in patients with COVID-19 infection.

Publication types

  • Review

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Anti-Inflammatory Agents / therapeutic use*
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections / drug therapy*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Inflammation / drug therapy*
  • Inflammation / virology
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral / drug therapy*
  • SARS-CoV-2

Substances

  • Anti-Inflammatory Agents
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2