Potential role of statins in COVID-19

Ken Cheah Hooi Lee; Duu Wen Sewa; Ghee Chee Phua

doi:10.1016/j.ijid.2020.05.115

Potential role of statins in COVID-19

Int J Infect Dis. 2020 Jul:96:615-617. doi: 10.1016/j.ijid.2020.05.115. Epub 2020 Jun 2.

Authors

Ken Cheah Hooi Lee¹, Duu Wen Sewa², Ghee Chee Phua²

Affiliations

¹ Department of Respiratory and Critical Care Medicine, Singapore General Hospital. Electronic address: ken.lee.c.h@singhealth.com.sg.
² Department of Respiratory and Critical Care Medicine, Singapore General Hospital.

Abstract

Patients with COVID-19 infection have an increased risk of cardiovascular complications and thrombotic events. Statins are known for their pleiotropic anti-inflammatory, antithrombotic and immunomodulatory effects. They may have a potential role as adjunctive therapy to mitigate endothelial dysfunction and dysregulated inflammation in patients with COVID-19 infection.

Publication types

Review

MeSH terms

Angiotensin-Converting Enzyme 2
Anti-Inflammatory Agents / therapeutic use*
Betacoronavirus
COVID-19
Coronavirus Infections / drug therapy*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Inflammation / drug therapy*
Inflammation / virology
Pandemics
Peptidyl-Dipeptidase A
Pneumonia, Viral / drug therapy*
SARS-CoV-2

Substances

Anti-Inflammatory Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2