A first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring EGFR exon 19 deletion

Diagn Pathol. 2020 Jun 6;15(1):71. doi: 10.1186/s13000-020-00986-0.


Background: Primary myoepithelial carcinoma of the lung is a rare subtype in lung cancer. Comprehensive molecular profiling of myoepithelial carcinoma of the lung is absent, neither was clinical evidence of targeted therapy available for this disease. Therefore, the optimal treatment regimen of this tumor needs to be established.

Case presentation: Here we present a case of a 68-year-old patient with stage IVB primary myoepithelial carcinoma of the lung who harbored EGFR exon 19 deletion and KRAS mutation and underwent icotinib targeted therapy, achieving partial response (PR) with progression free survival (PFS) of 3 months.

Conclusion: To our knowledge, this study describes the first documented case of primary myoepithelial carcinoma lung cancer patient harboring EGFR exon 19 deletion and KRAS mutation, and showed clinical efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) treatment in this patient.

Keywords: EGFR 19del; Icotinib; Lung; Myoepithelial carcinoma; Salivary gland type tumor.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / therapeutic use*
  • Crown Ethers / therapeutic use*
  • Disease-Free Survival
  • ErbB Receptors / genetics
  • Exons
  • Gene Deletion
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology
  • Male
  • Molecular Targeted Therapy / methods
  • Myoepithelioma / drug therapy*
  • Myoepithelioma / genetics
  • Myoepithelioma / pathology
  • Quinazolines / therapeutic use*
  • Smoking / adverse effects


  • Antineoplastic Agents
  • Crown Ethers
  • Quinazolines
  • icotinib
  • EGFR protein, human
  • ErbB Receptors