Alcohol consumption during adolescence alters the hippocampal response to traumatic brain injury

Biochem Biophys Res Commun. 2020 Jul 30;528(3):514-519. doi: 10.1016/j.bbrc.2020.05.160. Epub 2020 Jun 4.


Binge drinking is the consumption of large volumes of alcohol in short periods and exerts its effects on the central nervous system, including the hippocampus. We have previously shown that binge drinking alters mitochondrial dynamics and induces neuroinflammation in the hippocampus of adolescent rats. Mild traumatic brain injury (mTBI), is regularly linked to alcohol consumption and share mechanisms of brain damage. In this context, we hypothesized that adolescent binge drinking could prime the development of brain damage generated by mTBI. We found that alcohol binge drinking induced by the "drinking in the dark" (DID) paradigm increases oxidative damage and astrocyte activation in the hippocampus of adolescent mice. Interestingly, adolescent animals submitted to DID showed decreased levels of mitofusin 2 that controls mitochondrial dynamics. When mTBI was evaluated as a second challenge, hippocampi from animals previously submitted to DID showed a reduction in dendritic spine number and a different spine profile. Mitochondrial performance could be compromised by alterations in mitochondrial fission in DID-mTBI animals. These data suggest that adolescent alcohol consumption can modify the progression of mTBI pathophysiology. We propose that mitochondrial impairment and oxidative damage could act as priming factors, modifying predisposition against mTBI effects.

Keywords: Alcohol; Dendritic spine; Mitochondria; Oxidative stress; Traumatic brain injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Drinking / adverse effects*
  • Alcohol Drinking / pathology
  • Alcohol Drinking / physiopathology*
  • Animals
  • Binge Drinking / complications
  • Binge Drinking / pathology
  • Binge Drinking / physiopathology
  • Brain Injuries, Traumatic / complications
  • Brain Injuries, Traumatic / pathology
  • Brain Injuries, Traumatic / physiopathology*
  • Dendritic Spines / pathology
  • Disease Models, Animal
  • Hippocampus / pathology
  • Hippocampus / physiopathology*
  • Inflammation / etiology
  • Inflammation / pathology
  • Inflammation / physiopathology
  • Lipid Peroxidation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mitochondrial Dynamics / physiology
  • Oxidative Stress
  • Sexual Maturation / physiology*