Effects of hypothermia and hypothermia combined with hypocapnia on cerebral tissue oxygenation in piglets

Abstract

Background: Hypothermia and its combination with hypocapnia are frequently associated with anesthesia.

Aims: The goal was to investigate the effects of hypothermia and hypothermia combined with hypocapnia (hypothermia-hypocapnia) on cerebral tissue oxygenation in anesthetized piglets.

Methods: Twenty anesthetized piglets were randomly allocated to hypothermia (n = 10) or hypothermia-hypocapnia (n = 10). Cerebral monitoring comprised a tissue oxygen partial pressure (PtO₂ ), a laser Doppler probe, and a near-infrared spectroscopy sensor, measuring regional oxygen saturation (rSO₂ ). After baseline recordings, hypothermia (35.5-36.0°C) with or without hypocapnia (target PaCO₂ : 28-30 mm Hg) was induced. Once treatment goals were achieved (Tr0), they were maintained for 30 minutes (Tr30).

Results: No changes in PtO₂ but a significant increase in rSO₂ (Tr0 (mean difference 8.9[95% CI for difference3.99 to 13.81], P < .001); Tr30 (10.8[6.20 to 15.40], P < .001)) were detected during hypothermia. With hypothermia-hypocapnia, a decrease in PtO₂ (Tr0 (-3.2[-6.01 to -0.39], P = .021; Tr30 (-3.3[-5.8 to -0.80], P = .006)) and no significant changes in rSO₂ occurred. Cerebral blood flow decreased significantly from baseline to Tr0 independently of treatment (-0.89[-0.18 to -0.002], P = .042), but this was more consistently observed with hypothermia-hypocapnia.

Conclusions: The hypothermia-induced reduction in oxygen delivery was compensated by lowered metabolic demand. However, hypothermia was not able to compensate for an additional reduction in oxygen delivery caused by simultaneous hypocapnia. This resulted in a PtO₂ drop, which was not reflected by a downshift in rSO₂ .

Keywords: anesthesia; cerebral circulation; cerebral oxygenation; hypocapnia; hypothermia; inhalation; swine.