Hyaluronic acid-Based wound dressings: A review

Carbohydr Polym. 2020 Aug 1;241:116364. doi: 10.1016/j.carbpol.2020.116364. Epub 2020 Apr 27.


Hyaluronic acid (HA), a non-sulfated glycosaminoglycan (GAG), is a major component of skin extracellular matrix (ECM) and it is involved in the inflammatory response, angiogenesis, and tissue regeneration process. Due to the intrinsic properties of HA (such as biocompatibility, biodegradability and hydrophilic character), it has been used to produce different wound dressings, namely sponges, films, hydrogels, and electrospun membranes. Herein, an overview of the different HA-based wound dressings that have been produced so far is provided as well as the future directions regarding the strategies aimed to improve the mechanical stability of HA-based wound dressings, along with the incorporation of biomolecules intended to ameliorate their biological performance during the healing process.

Keywords: Hyaluronic acid; Wound dressing; Wound healing.

Publication types

  • Review

MeSH terms

  • Animals
  • Bandages*
  • Cell Line
  • Humans
  • Hyaluronic Acid* / analogs & derivatives
  • Hyaluronic Acid* / chemistry
  • Hyaluronic Acid* / pharmacology
  • Hydrogels* / chemistry
  • Hydrogels* / pharmacology
  • Skin / drug effects*
  • Skin / pathology
  • Wound Healing*


  • Hydrogels
  • Hyaluronic Acid