Contemporary management of ovarian germ cell tumors and remaining controversies

Gynecol Oncol. 2020 Aug;158(2):467-475. doi: 10.1016/j.ygyno.2020.05.007. Epub 2020 Jun 5.


Ovarian germ cell tumors (GCTs) are rare in adults, but are more common in adolescents and young adults. Contemporary management of ovarian GCTs is evolving as collaboration among pediatric, medical, and gynecologic oncologists increases, and studies increasingly incorporate female adult patients. Despite an improved understanding of ovarian GCT, many questions remain. Areas of continued controversy include which stage I ovarian GCTs and immature teratomas can be observed without adjuvant therapy, appropriate risk classification for ovarian GCT, surveillance strategies, and optimal therapy for recurrence. These topics as well as active areas of clinical investigation are discussed.

Keywords: Germ cell tumor; Ovarian cancer; Teratoma; microRNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Clinical Trials, Phase III as Topic
  • Female
  • Humans
  • Neoplasms, Germ Cell and Embryonal / diagnosis*
  • Neoplasms, Germ Cell and Embryonal / therapy*
  • Ovarian Neoplasms / diagnosis*
  • Ovarian Neoplasms / therapy*
  • Randomized Controlled Trials as Topic
  • Teratoma / diagnosis
  • Teratoma / therapy

Supplementary concepts

  • Teratoma, Ovarian