Adult T-cell leukemia/lymphoma (ATLL) is a peripheral (mature) T-cell lymphoma (PTCL) caused by human T-cell leukaemia virus type 1 (HTLV-I). HTLV-I is prevalent in Japan, the Caribbean, Romania, and certain regions of Africa and Latin America. Taiwan is a country non-endemic for HTLV-I infection, with a low seroprevalence rate at 0.058-1.72%. ATLL shows diverse clinical manifestations and histology with several clinical variants including acute, lymphomatous, chronic, and smoldering.
Keywords: HBZ; CD30; HTLV-1 bZIP factor gene; adult T-cell leukemia/lymphoma; anaplastic large cell lymphoma; human T-cell leukemia virus type 1.
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