Sustainability of a Clinical Examination-Based Approach for Ascertainment of Early-Onset Sepsis in Late Preterm and Term Neonates

J Pediatr. 2020 Oct;225:263-268. doi: 10.1016/j.jpeds.2020.05.055. Epub 2020 Jun 5.


We demonstrated the sustained impact over a 5-year period of a clinical examination-based approach to identification of early-onset sepsis in late preterm and term neonates at our hospital. To date, more than 20 000 neonates have been safely managed using this approach, resulting in a 63% reduction in antibiotic use.

Keywords: antibiotics; antimicrobial stewardship.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Cohort Studies
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Interrupted Time Series Analysis
  • Neonatal Screening / methods*
  • Neonatal Sepsis / diagnosis*
  • Neonatal Sepsis / drug therapy
  • Pregnancy
  • Quality Improvement


  • Anti-Bacterial Agents