Marked lateral ST-segment elevation with inferior ST-segment depression in an asymptomatic 12 year-old girl: A normal variant?

J Electrocardiol. Jul-Aug 2020;61:23-26. doi: 10.1016/j.jelectrocard.2020.05.011. Epub 2020 May 18.


Significant ST-segment changes raise concern for myocardial ischemia, cardiomyopathy or myocardial inflammation and therefore, warrant an extensive and often invasive cardiovascular evaluation. We report a 12 year-old asymptomatic African-American girl with marked ST-segment elevation in leads I and aVL and ST-segment depression in inferior leads II, III and aVF. Extensive cardiovascular evaluation did not reveal any abnormality suggesting that these findings, which have previously not been reported, are likely benign, at least in this young girl.

Keywords: Asymptomatic; Benign; P.L1308R MYH6 variant of uncertain significance; ST-segment depression; ST-segment elevation.

Publication types

  • Case Reports

MeSH terms

  • Arrhythmias, Cardiac
  • Child
  • Depression
  • Electrocardiography
  • Female
  • Humans
  • Myocardial Infarction*
  • Myocardial Ischemia* / diagnosis