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Randomized Controlled Trial
. 2020 Jun 4;12(6):1671.
doi: 10.3390/nu12061671.

Effect of Porcine Placenta Extract Supplement on Skin Condition in Healthy Adult Women: A Randomized, Double-Blind Placebo-Controlled Study

Masumi Nagae  1 , Maki Nagata  1 , Mitsuhiro Teramoto  2 , Masayuki Yamakawa  2 , Takahiro Matsuki  2 , Koichiro Ohnuki  3 , Kuniyoshi Shimizu  1
Affiliations
Free PMC article
Randomized Controlled Trial

Effect of Porcine Placenta Extract Supplement on Skin Condition in Healthy Adult Women: A Randomized, Double-Blind Placebo-Controlled Study

Masumi Nagae et al. Nutrients. .
Free PMC article

Abstract

Placenta extract has been used as a component of ointments for skin dryness and beautification. However, little is known about the effect of oral intake of placenta extract on skin condition. The current study aimed to clinically explore the effect of oral intake of porcine placenta extract on human skin quality. A randomized controlled double-blind trial was performed on healthy women aged 40-59 years (n = 20), who were randomly assigned to receive either placebo or 200 mg of porcine placenta extract once daily for 4 weeks from 28 January 2019 to 25 February 2019. Skin quality parameters and the Simplified Menopausal Index (SMI) were assessed at baseline and after 4 weeks. After 4 weeks, three parameters of skin quality were significantly improved in the porcine placenta group compared with the placebo group. These results suggest that porcine placenta extract can be used as a health food ingredient to maintain humans' skin condition in the dry winter season.

Keywords: menopausal symptoms; porcine placenta extract; skin barrier function; skin elasticity; skin hydration.

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Conflict of interest statement

M.T., M.Y., and T.M. are employees of Kasyu Industries Co., Ltd., Inc. Except for supplement contribution, the funding sources had no role in the design, conduct, or analysis of the study or the decision to submit the manuscript for publication. All the other authors declare no competing interests.

Figures

Figure A1
Figure A1
Expression of ceramide synthase in human keratinocyte cells (HaCaT) cells after porcine placenta extract application.
Figure A2
Figure A2
Effect of porcine placenta extract on HaCaT cell viability.
Figure 1
Figure 1
The study flow diagram.
Figure 2
Figure 2
Effect of porcine placenta extract on menopausal symptoms. Comparison of changes of Simplified Menopausal Index (SMI) over 4 weeks between the placebo group and test group.
See this image and copyright information in PMC

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