What is the role of supplementation with ascorbic acid, zinc, vitamin D, or N-acetylcysteine for prevention or treatment of COVID-19?

Seth R Bauer; Aanchal Kapoor; Mary Rath; Suma A Thomas

doi:10.3949/ccjm.87a.ccc046

What is the role of supplementation with ascorbic acid, zinc, vitamin D, or N-acetylcysteine for prevention or treatment of COVID-19?

Cleve Clin J Med. 2020 Jun 8. doi: 10.3949/ccjm.87a.ccc046. Online ahead of print.

Authors

Seth R Bauer¹, Aanchal Kapoor², Mary Rath³, Suma A Thomas⁴

Affiliations

¹ Department of Pharmacy, Cleveland Clinic.
² Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic.
³ Center for Human Nutrition, Digestive Disease & Surgery Institute, Cleveland Clinic.
⁴ Department of Cardiovascular Medicine, Heart, Vascular, and Thoracic Institute, Cleveland Clinic.

PMID: 32513807
DOI: 10.3949/ccjm.87a.ccc046

Abstract

Several agents intended to supplement dietary intake or endogenous molecules may have a theoretical role in preventing or treating COVID-19. Because of their potential to influence immune response, ascorbic acid (vitamin C), zinc, vitamin D, and N-acetylcysteine have been hypothesized to be useful for prevention or treatment of COVID-19. The authors outline the biologic plausibility, applicable clinical data, and potential role of each of these agents.