Dissecting antibody-mediated protection against SARS-CoV-2

Nat Rev Immunol. 2020 Jul;20(7):392-394. doi: 10.1038/s41577-020-0359-5. Epub 2020 Jun 8.


Understanding the properties and mechanisms by which antibodies provide protection is essential to defining immunity. Although neutralizing antibodies have been proposed as a potential key mechanism of protection against many viral pathogens, antibodies mediate additional immune functions that may have both protective and pathological consequences. Dissecting these properties against SARS-CoV-2 is likely necessary for defining metrics of immunity that will inform the design of vaccines and therapeutics and improve clinical management.

MeSH terms

  • Animals
  • Antibodies, Neutralizing / immunology
  • Antibodies, Viral / blood
  • Antibodies, Viral / immunology*
  • Antibody-Dependent Cell Cytotoxicity
  • Antibody-Dependent Enhancement
  • COVID-19
  • COVID-19 Vaccines
  • Coronavirus Infections / immunology*
  • Coronavirus Infections / prevention & control
  • Humans
  • Pandemics
  • Pneumonia, Viral / immunology*
  • Viral Vaccines / immunology


  • Antibodies, Neutralizing
  • Antibodies, Viral
  • COVID-19 Vaccines
  • Viral Vaccines