The CSF Levels of Neutrophil-Related Chemokines in Patients with Neuromyelitis Optica

Ann Clin Transl Neurol. 2020 Jul;7(7):1245-1251. doi: 10.1002/acn3.51094. Epub 2020 Jun 9.

Abstract

Pathologic findings showed that neutrophils played an important role in the pathogenesis of NMO. This study aims to investigate the CSF levels of neutrophil-related chemokines in NMO. CXCL1, CXCL5, and CXCL7 were measured in 95 patients with NMO, 15 patients with MS, 18 patients with GFAP astrocytopathy, and 16 controls. The CSF level of CXCL1, CXCL5, and CXCL7 was significantly elevated in the NMO group but not correlated with the patient clinical severity. Besides, the CSF CXCL1, CXCL5, and CXCL7 could act as biomarkers to distinguish NMO from MS with good reliability, especially the CXCL7.

Keywords: CXCL1; CXCL5; CXCL7; neuromyelitis optica; neutrophil-related chemokines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chemokine CXCL1 / cerebrospinal fluid*
  • Chemokine CXCL5 / cerebrospinal fluid*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuromyelitis Optica / cerebrospinal fluid*
  • Neuromyelitis Optica / physiopathology
  • Neutrophil Activation*
  • Severity of Illness Index
  • beta-Thromboglobulin / cerebrospinal fluid*

Substances

  • CXCL1 protein, human
  • CXCL5 protein, human
  • Chemokine CXCL1
  • Chemokine CXCL5
  • PPBP protein, human
  • beta-Thromboglobulin

Grants and funding

This work was funded by Guangdong Provincial Science and Technology plan projects grant 2017A020215182; Guangzhou Science and Technology Project grant 201704020111; National Natural Science Foundation of China grants 2017A020215182 and 201704020111; Natural Science Foundation of Guangdong Province grant 2019A1515011434 2019A1515011611.