A case series of patients with gonadal dysgenesis-associated mixed malignant ovarian germ cell tumor

Gynecol Endocrinol. 2020 Oct;36(10):934-937. doi: 10.1080/09513590.2020.1775194. Epub 2020 Jun 9.


Introduction: Malignant germ cell tumors (MGCT) can occur in both genders. In this study, we present eight cases of mixed ovarian MGCT in patients. Most patients reported in the current study are young women, among whom clinical characteristics of gonadal dysgenesis associated MGCT were rarely reported.Methods: Comprehensive information of eight patients with mixed ovarian MGCTs, including patients' age, clinical features, tumor markers, imaging findings, surgical records, pathology, karyotyping tests, chemotherapy and follow-up were collected. Surgical specimens were evaluated by two specialized gynecologic pathologists.Results: All patients received surgery, while seven received chemotherapy. Among them, two received a second surgery and three patients received hormone replacement therapy (HRT) after gonadectomy. Four of five patients with amenorrhea were found to have 46, XY karyotype. All patients showed no sign of recurrence at the latest follow-up.Discussion: Karyotyping or genetics testing in patients with amenorrhea is necessary, especially for patients with pelvic mass, which can help surgeons to evaluate the necessity of gonadectomy before surgery. The patients with gonadal dysgenesis associated mixed ovarian MGCT seem to have better prognosis and long survival time. Thus, HRT, an option that can improve life quality, is worth considering for these patients after gonadectomy.

Keywords: Mixed malignant germ cell tumors; gonadal dysgenesis; gonadectomy; hormone replacement therapy.

MeSH terms

  • Adolescent
  • Adult
  • Antineoplastic Agents / therapeutic use
  • Female
  • Gonadal Dysgenesis / complications*
  • Gynecologic Surgical Procedures
  • Hormone Replacement Therapy
  • Humans
  • Neoplasms, Germ Cell and Embryonal / drug therapy
  • Neoplasms, Germ Cell and Embryonal / etiology*
  • Neoplasms, Germ Cell and Embryonal / pathology
  • Neoplasms, Germ Cell and Embryonal / surgery
  • Ovarian Neoplasms / drug therapy
  • Ovarian Neoplasms / etiology*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery
  • Ovary / pathology
  • Retrospective Studies
  • Young Adult


  • Antineoplastic Agents

Supplementary concepts

  • Ovarian Germ Cell Cancer