Selective Targeting of Different Bromodomains by Small Molecules

Jun Qi; Yang Shi

doi:10.1016/j.ccell.2020.05.016

Selective Targeting of Different Bromodomains by Small Molecules

Cancer Cell. 2020 Jun 8;37(6):764-766. doi: 10.1016/j.ccell.2020.05.016.

Authors

Jun Qi¹, Yang Shi²

Affiliations

¹ Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: jun_qi@dfci.harvard.edu.
² Division of Newborn Medicine and Epigenetics Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address: yang_shi@childrens.harvard.edu.

PMID: 32516588
DOI: 10.1016/j.ccell.2020.05.016

Abstract

Two papers, published in Science and Nature, report inhibitiors selectively targeting distinct bromodomains of BET proteins. These advanced chemical tools facilitate functional understanding of epigenetic regulators in normal and disease states and enable development of new medicine potentially with lower toxicity.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Humans
Male
Prostatic Neoplasms*
Protein Domains
Proteins*

Substances

Proteins

Grants and funding

R01 CA222218/CA/NCI NIH HHS/United States