Understanding Complexity of Cancer Genomes: Lessons from Errors

Sara Martin; Stefano Santaguida

doi:10.1016/j.devcel.2020.05.004

Understanding Complexity of Cancer Genomes: Lessons from Errors

Dev Cell. 2020 Jun 8;53(5):500-502. doi: 10.1016/j.devcel.2020.05.004.

Authors

Sara Martin¹, Stefano Santaguida²

Affiliations

¹ Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS, Milan, Italy.
² Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy. Electronic address: stefano.santaguida@ieo.it.

PMID: 32516595
DOI: 10.1016/j.devcel.2020.05.004

Abstract

Deconstructing the events leading to cancer genome rearrangements is key to understanding tumorigenesis. In a recent issue of Science, Umbreit, Zhang et al. elegantly show that complex genome evolution is the result of a cascade of events initiated by a single error during cell division.

Publication types

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MeSH terms

Carcinogenesis
Chromothripsis*
DNA Damage
Genome / genetics
Humans
Neoplasms* / genetics