Anti-Ku antibody-positive systemic sclerosis-polymyositis overlap syndrome in an adolescent

Rory J Loo; James J Nocton; Matthew M Harmelink; Yvonne E Chiu

doi:10.1111/pde.14243

Anti-Ku antibody-positive systemic sclerosis-polymyositis overlap syndrome in an adolescent

Pediatr Dermatol. 2020 Sep;37(5):960-961. doi: 10.1111/pde.14243. Epub 2020 Jun 10.

Authors

Rory J Loo¹, James J Nocton², Matthew M Harmelink³, Yvonne E Chiu⁴

Affiliations

¹ Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
² Department of Pediatrics (Rheumatology), Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
³ Department of Neurology (Child Neurology), Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
⁴ Departments of Dermatology (Pediatric Dermatology) and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

PMID: 32519400
DOI: 10.1111/pde.14243

Abstract

Systemic sclerosis-polymyositis overlap syndrome is rare in children. Anti-PM/Scl is the most common autoantibody associated with this syndrome. We present a case of systemic sclerosis-polymyositis overlap syndrome in a child with isolated anti-Ku antibodies, an uncommon antibody associated with this rare syndrome.

Keywords: anti-Ku antibody; myositis; overlap syndrome; polymyositis; scleroderma.

Publication types

Case Reports

MeSH terms

Adolescent
Autoantibodies
Humans
Polymyositis*
Scleroderma, Systemic* / complications
Scleroderma, Systemic* / diagnosis

Substances

Autoantibodies