COVID-19 in lung transplant recipients

Transpl Infect Dis. 2020 Dec;22(6):e13364. doi: 10.1111/tid.13364. Epub 2020 Jul 22.

Abstract

Solid organ transplant recipients are considered at high risk for COVID-19 infection due to chronic immune suppression; little data currently exists on the manifestations and outcomes of COVID-19 infection in lung transplant recipients. Here we report 8 cases of COVID-19 identified in patients with a history of lung transplant. We describe the clinical course of disease as well as preexisting characteristics of these patients.

Keywords: COVID-19; immune suppression; lung transplant.

MeSH terms

  • Adenosine Monophosphate / analogs & derivatives
  • Adenosine Monophosphate / therapeutic use
  • Adult
  • Aged
  • Alanine / analogs & derivatives
  • Alanine / therapeutic use
  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Antiviral Agents / therapeutic use
  • COVID-19 / diagnostic imaging
  • COVID-19 / immunology
  • COVID-19 / physiopathology*
  • COVID-19 / therapy
  • Cough / physiopathology
  • Cross Infection / diagnostic imaging
  • Cross Infection / immunology
  • Cross Infection / physiopathology*
  • Cross Infection / therapy
  • Cystic Fibrosis / surgery
  • Dyspnea / physiopathology
  • Female
  • Fever / physiopathology
  • Gastrointestinal Diseases / physiopathology
  • Glucocorticoids / therapeutic use
  • Graft Rejection / prevention & control
  • Humans
  • Idiopathic Pulmonary Fibrosis / surgery
  • Immunoglobulins, Intravenous / therapeutic use
  • Immunologic Factors / therapeutic use
  • Immunosuppressive Agents / therapeutic use*
  • Interleukin 1 Receptor Antagonist Protein / therapeutic use
  • Lung / diagnostic imaging
  • Lung Transplantation*
  • Male
  • Methylprednisolone / therapeutic use
  • Middle Aged
  • Pancreatitis, Acute Necrotizing
  • Pulmonary Disease, Chronic Obstructive / surgery
  • Pulse Therapy, Drug
  • SARS-CoV-2
  • Sepsis
  • Severity of Illness Index
  • Tomography, X-Ray Computed

Substances

  • Antibodies, Monoclonal, Humanized
  • Antiviral Agents
  • Glucocorticoids
  • Immunoglobulins, Intravenous
  • Immunologic Factors
  • Immunosuppressive Agents
  • Interleukin 1 Receptor Antagonist Protein
  • remdesivir
  • Adenosine Monophosphate
  • tocilizumab
  • Alanine
  • Methylprednisolone