Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group 'Molecular Diagnostics and Therapy'

Eur J Cancer. 2020 Aug;135:1-7. doi: 10.1016/j.ejca.2020.04.019. Epub 2020 Jun 7.


Precision cancer medicine (PCM) holds great promises to offer more effective therapies to patients based on molecular profiling of their individual tumours. Although the PCM approach seems intuitive, multiple conceptional and structural challenges interfere with the broad implementation of PCM into clinical practice. Accordingly, concerted national and international efforts are needed to guide the further development and broad adoption of PCM in Germany. With support of the 'German Cancer Aid' (Deutsche Krebshilfe [DKH]) a task force 'Molecular Diagnostics and Therapy' was implemented. In two workshops supported by the DKH, delegates from the fourteen comprehensive cancer centresidentified key topics essential to implement quality-guided, harmonized and adaptable PCM. Based on an online questionnaire and using a modified Delphi approach, nine statements were drafted and evaluated within the group. These statements could serve as a basis to define a collaborative strategy for PCM in the future with the aim to sustain and further improve its quality.

Keywords: Genomic profiling; Molecular diagnostics; Molecular tumour board; Precision medicine; Precision oncology.

Publication types

  • Consensus Development Conference
  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Consensus
  • Delphi Technique
  • Germany
  • Humans
  • Molecular Diagnostic Techniques / standards*
  • Molecular Targeted Therapy / standards*
  • Neoplasms / diagnosis*
  • Neoplasms / genetics
  • Neoplasms / therapy*
  • Precision Medicine / standards*
  • Predictive Value of Tests
  • Research Design / standards*


  • Antineoplastic Agents