The Expression of KI-67 and LEF-1 in Patients After Breast Cancer Resection and Its Effects on Patients' Prognosis

J BUON. Mar-Apr 2020;25(2):627-633.

Abstract

Purpose: To investigate the expression of KI-67 and LEF-1 in patients after breast cancer resection and its effects on patients' prognosis.

Methods: A total of 89 breast cancer patients admitted to the first affiliated Hospital of Shantou University Medical College from January 2010 to February 2013 were enrolled as the study group, and 76 healthy individuals were enrolled as the control group. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression of KI-67 and LEF-1 in the serum. The relationship of the two indexes and clinicopathological data of the breast cancer patients were analyzed. In addition, the diagnostic value of KI-67 and LEF-1 in breast cancer patients was analyzed by receiver operating characteristic (ROC) curves, and their diagnostic value in the postoperative 5-year recurrence was also analyzed. Furthermore, the expression of KI-67 and LEF-1 in patients with postoperative recurrent breast cancer within 5 years was evaluated.

Results: The expression of KI-67 and LEF-1 in the study group was higher than in the control group (p<0.05), and the expression of KI-67 and LEF-1 was significantly related to the tumor size and lymph node metastasis (both p<0.05). ROC curve showed that the area under the curve (AUC) of the diagnostic value of KI-67 and LEF-1 for breast cancer patients was 0.860 and 0.858 respectively, and that of the diagnostic value KI-67 combined with LEF-1 for breast cancer patients was 0.924. In addition, the AUC of the diagnostic value of KI-67 and LEF-1 for the recurrence of breast cancer within 5 years was 0.699 and 0.651, respectively, and that of diagnostic value of KI-67 combined with LEF-1 for the recurrence of breast cancer within 5 years was 0.758. The expression of KI-67 and LEF-1 in patients with recurrent disease within 5 years after operation was higher than in patients without recurrence.

Conclusion: The expression of KI-67 and LEF-1 in breast cancer patients is significantly higher than in healthy individuals, which has certain diagnostic value in breast cancer. The expression of the two indexes is related to tumor size and lymph node metastasis, and the survival of patients with high expression of KI-67 and LEF-1 is worse.